Investigative Toxicology Junior Scientist

At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters.

The Position

In Roche’s Pharmaceutical Research and Early Development organisation (pRED), we make transformative medicines for patients to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility, and humility, where our talented people are empowered and inspired to bring forward extraordinary, life-changing innovation at speed.

At the intersection of science and innovation, pRED’s Pharmaceutical Sciences (PS) organisation enables the discovery and development of safe and effective therapeutics at optimal doses in relevant populations with a vision to power translation, continuously improve the accuracy of our predictions and accelerate the development of tomorrow's medicines. By seamlessly integrating our three core pillars—Translational Safety, Translational Pharmacology, and Biomarkers—we drive end-to-end asset development across the entire value chain, from target assessment to on-market support. Our mission is to continuously improve predictive accuracy, optimise dosing strategies for the right patient populations, and accelerate the development of tomorrow's safe and effective therapeutics.

This position is located in Pathology and Applied Safety Science, a department within the Pharmaceutical Sciences function. We drive the non-clinical safety assessment of drug candidates from small molecules to complex biological products during the discovery and development phases at Roche.

The Opportunity

As an engaged Junior Investigative Toxicology Scientist within our Pathology and Applied Safety Science department, you will play a pivotal role in the development, validation, and implementation of nonclinical assays for translational safety assessment. Your primary responsibility will be to propose, conduct, and report investigative toxicology experiments to understand mechanisms of toxicity and predict toxicity liabilities of early drug series. Leveraging modern tools to maximise scientific insights and drive innovation, you will support the development of in vitro predictive safety models and remain accountable for the scientific delivery of modern toxicology assays to inform risk assessment across projects ranging from small molecules to complex biological products. The Junior Investigative Toxicology Scientist is primarily a wet lab-focused position with the majority of time dedicated to hands-on experimental work in the lab.

• Scientific Strategy & In Vitro Model Development: Design, develop, optimise, and perform in vitro toxicology assays, including advanced 2D and 3D human cell models, to support translational safety assessment and predict toxicity liabilities of early drug candidates.
• Advanced Analytical Workflows & High-Content Imaging: Drive proficiency in state-of-the-art analytical methods (including high-content screening, confocal imaging platforms, and next-generation sequencing) while building, deploying, and maintaining custom image analysis tools and automated pipelines to extract metrics from complex cellular setups, collaborating closely with digital engineering, bioinformatics, and digital pathology teams to scale cell data into accessible project arrays
• Data Curation, Laboratory Information Management System (LIMS), & Reporting: Conduct rigorous data analysis, critical procedure evaluations, and proper internal reporting of