Digital Pathologist

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Die Position

In Roche’s Pharmaceutical Research and Early Development organisation (pRED), we make transformative medicines for patients to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility, and humility, where our talented people are empowered and inspired to bring forward extraordinary, life-changing innovation at speed.

At the intersection of science and innovation, pRED’s Pharmaceutical Sciences (PS) organisation enables the discovery and development of safe and effective therapeutics at optimal doses in relevant populations with a vision to power translation, continuously improve the accuracy of our predictions and accelerate the development of tomorrow's medicines. By seamlessly integrating our three core pillars—Translational Safety, Translational Pharmacology, and Biomarkers—we drive end-to-end asset development across the entire value chain, from target assessment to on-market support. Our mission is to continuously improve predictive accuracy, optimise dosing strategies for the right patient populations, and accelerate the development of tomorrow's safe and effective therapeutics.

This position is located in Pathology and Applied Safety Science, a department within the Pharmaceutical Sciences function. We drive the non-clinical safety assessment of drug candidates from small molecules to complex biological products during the discovery and development phases at Roche.

The Opportunity

As an engaged Digital Pathologist, you will play a pivotal role in the development, validation, and implementation of pathology investigations and the application of computational pathology approaches for translational safety assessment. Your primary responsibility will be to propose, conduct, and report computational toxicologic pathology approaches to understand mechanisms of toxicity, leveraging modern tools to maximise scientific insights, drive innovation, and advance our therapeutic pipeline. You will support the automation of pathology algorithms, workflows, and platforms, remaining accountable for the scientific delivery of pathology data to inform risk assessment across projects ranging from small molecules to complex biological products.

• Core Portfolio Toxicologic Pathology: Provide expert pathology support in preclinical development, aligning toxicity study designs with current science and regulatory guidelines. Conduct qualitative and quantitative (histo)pathologic evaluations for discovery and development toxicology studies, including GLP-compliant studies. Peer-review histopathologic data and interpretations from internal or CRO pathologists per established SOPs. Integrate clinical pathology data (haematology, clinical chemistry) with histopathology findings for a holistic, mechanistic interpretation of toxicity. Deliver clear, concise test result interpretations and author pathology sections for Research Reports, regulatory filings (e.g., IND/CTA), and governance presentations.
• Algorithm Architecture& Image Analysis Deployment: Propose, build, test, and implement custom image analysis solutions and algorithms to automate cell and biomarker quantification on scanned tissue. Oversee the integration of ML and non-ML software to detect, segment, and score complex tissue morphologies